Definition
AAV (Adeno-Associated Virus) is a small, non-enveloped, single-stranded DNA virus widely used in gene therapy due to its low immunogenicity and strong safety profile. It is considered one of the most effective and reliable gene delivery vehicles for in vivo applications.
Clinical Value
AAV vectors enable efficient and targeted delivery of therapeutic genes to a variety of tissues — particularly the central nervous system, liver, retina, and muscle. With multiple serotypes and engineered capsids available, AAV offers versatile targeting capabilities and is widely used in the treatment of genetic disorders, neurodegenerative diseases, and ocular conditions.
OranssiBio Advantages
- 01
GMP-compliant manufacturing platform designed to ensure product quality and safety - 02
Production capabilities across multiple AAV serotypes, including AAV2, AAV5, AAV6, AAV8, and AAV9 - 03
Scalable serum-free suspension process, supporting volumes up to 400L for both clinical and commercial needs - 04
End-to-end services from process and assay development to GMP manufacturing and QC
Service Highlights
Customized process development tailored to project needs
Comprehensive analytical support to ensure product quality and stability
Fast project turnaround and agile execution
Experienced team offering technical and regulatory guidance
Key Specifications
| Technical Specifications | Technical Parameters |
|---|---|
| Scale | 0.1L–400L |
| Serotypes | AAV2, AAV5, AAV6, AAV8, AAV9 |
| Purification | Chromatography, ultrafiltration |
| QC Methods | Titer, purity, residual DNA, and more |
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